Facts about Tramadol

Tramadol is a narcotic-like pain reliever. It is used to treat moderate to severe pain and to moderate to severe chronic pain.

Tramadol should not be taken if the patient has a history of alcohol or drug addiction. It should not be taken also if you are intoxicated.

Symptoms of overdose may include:

Decreased size of the pupil (the black circle in the center of the eye), difficulties in breathing, extreme drowsiness, unconsciousness, coma, seizure and heart attack.

Important Reminders before taking Tramadol:

Take tramadol exactly as it was prescribed for you. Do not take more than 300 milligrams in one day. Do not stop using this medication without talking to your doctor. You may in time need to slowly reduce the dose. Withdrawal symptoms may occur when you stop using tramadol and they are the following: anxiety, sweating, nausea, diarrhea, tremors, chills, hallucinations, trouble sleeping, or breathing problems. Call your doctor right away if you experience any of those symptoms.

A tramadol overdose can be fatal. So while you are taking tramadol, do not drink alcohol or use a drug that makes you sleepy (such as cold medicine, other pain medications, and muscle relaxants, medicine for seizures, depression or anxiety).

These drugs may slow your breathing or increase drowsiness when used together with tramadol. Like any other drug, tramadol can cause side effects that may impair your thinking or give you allergic reactions. It is not advisable to take this medicine when you are planning to drive or requires you to do anything that you need to be mentally alert.

Tell your doctor if you are allergic to any drugs, or if you have kidney disease, liver disease, a stomach disorder or history of mental illness or suicide attempts in the past. Do not use tramadol during pregnancy; it may be harmful to the unborn baby. It can cause fatal side effects in a new born if the mother uses the medication during pregnancy.

The Significance of using Cyclobenzaprine Drug

Cyclobenzaprine is a muscle relaxant. It works by blocking nerve impulses (or pain sensations) that are sent to your brain. It s a skeletal muscle relaxant and a central nervous system (CNS) depressant. It is used to relieve pain, tenderness, and limitation of motion caused by muscle spasms. The duration for taking this drug is basically for short term treatments that goes for 2 to 3 weeks. It is best to take this while resting or during physical therapy.

The exact mechanism of action for cyclobenzaprine is unknown. Current research appears to indicate that cyclobenzaprine acts on the locus coeruleus where it results in increased norepinephrine release, potentially through the gamma fibers which innervate and inhibit the alpha motor neurons in the ventral horn of the spinal cord.

The decreased firing of the alpha motor neuron results in reducing muscular tone. Cyclobenzaprine is a muscle relaxant acting primarily on the central nervous system. It is structurally similar to Amitriptyline, differing by only one double bond. Cyclobenzaprine is a weak inhibitor of presynaptic, norepinephrine, and serotonin. Skeletal muscle relaxant activity is due to brainstem mediated inhibition of gamma motor neurons

The standard side effects of Cyclobenzaprine includes drowsiness, depression, headaches, dizziness, and blurred vision. It's long term used has been associated with vision damage. Another side effects are dryness of the mouth, respiratory depression,decreased functionality in various muscles, and agitation ----which is a commonly found in elderly people.

Although allegedly obnoxious, cyclobenzaprine is moderately benevolent in case of overdose, depending on its toxicity level and also on the susceptibility of the user. Take note that the cyclobenzaprine damaging effects increases when used in conjunction with other drugs, particularly that deals with nervous system depressants and anti- depressants.

The use of cyclobenzaprine with an MAOI (monoamine oxidase inhibitor) will possibly result in fatality. A case of rhabdomyolysis (muscle breakdown) associated with its overdose has been reported in some scientific literatures. This is a rare but potentially fatal complication. Therefore, follow treatment protocols just as the same for any tricyclic anti- depressant.

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